General Information
- The three types of Agitoin are homologous, differing only slightly in their amino acid sequence, molecular weight and molecular formulas.
- The characteristics of each Agitoxin type are known, however Agitoxin Type II is most commonly seen in literature.
- There is a certain variability in K+ channels, and Agitoxin Type II has the highest affinity for the greatest number of K+ channel derivatives. (1.)
Mechanism
Each type of Agitoxin utilizes the same mechanism:
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In Research
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Sources:
1. Garcia, M., Garcia-Calvo, M., Hidalgo, P., Lee, A., and MacKinnon, R. Purification and Characterization of Three Inhibitors of Voltage-Dependent K+ Channels from Leiurus quinquestriatus var. hebraeus Venom. Biochemistry. 1994. No: 33, 6834-6839.
2. Bergeron, Z. and Bingham, J. Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering. Toxins. 2012. No: 4, 1082-1119
3. Greenberger, M. and Samson, A. Normal mode dynamics of voltage-gated K+ channels: gating principal, opening mechanism, and inhibition. Journal of Computational Neuroscience. 2014.
4. Kudryashova, K., Nekrasova, O., Kuzmenkov, A., Vassilevski, A., Ignatova, A., Korolkova, Y., Grishin, E., Kirpichnikov, M., and Feofanov, A. Fluorescent system based on bacterial expression of hyprid KcsA channels designed for Kv1.3 ligand screening and study. Analytical and Bioanalytical Chemistry. 2013. No: 405, 2379-2389.
1. Garcia, M., Garcia-Calvo, M., Hidalgo, P., Lee, A., and MacKinnon, R. Purification and Characterization of Three Inhibitors of Voltage-Dependent K+ Channels from Leiurus quinquestriatus var. hebraeus Venom. Biochemistry. 1994. No: 33, 6834-6839.
2. Bergeron, Z. and Bingham, J. Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering. Toxins. 2012. No: 4, 1082-1119
3. Greenberger, M. and Samson, A. Normal mode dynamics of voltage-gated K+ channels: gating principal, opening mechanism, and inhibition. Journal of Computational Neuroscience. 2014.
4. Kudryashova, K., Nekrasova, O., Kuzmenkov, A., Vassilevski, A., Ignatova, A., Korolkova, Y., Grishin, E., Kirpichnikov, M., and Feofanov, A. Fluorescent system based on bacterial expression of hyprid KcsA channels designed for Kv1.3 ligand screening and study. Analytical and Bioanalytical Chemistry. 2013. No: 405, 2379-2389.
By: Stephanie Dilts